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Neither is an approved cosmetic product Only afamelanotide (Scenesse), Melanotan I's medical version, is FDA-approved, and only for EPP
A 2025 pooled analysis showed meaningful weight loss across all menopause stages: Pre-menopausal women: 18.2% average weight loss Peri-menopausal women: 15.0% average weight loss Post-menopausal women: 15.7% average weight loss The hormonal changes of perimenopause declining estrogen, increasing insulin resistance, redistribution of fat toward the abdomen are often precisely what makes weight management feel impossible during midlife
The mechanisms that ensure this extended effect vary
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